State Key Laboratory of Biomembrane and Membrane Biotechnology

Name:	TANG, Tie-Shan
Subject:	Cell Biology
Tel/Fax:	+86-10-64807296 /
E-mail:	tangtsh@ioz.ac.cn, tangtsh@yahoo.com
Address:	State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Siences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
More:	Group of Molecular and Cellular Neuroscience 中文

Resume:

Ph.D. in Cell and Developmental Biology, CAS Institute of Developmental Biology, 1998

Research Associate, CAS Institute of Developmental Biology, 1998-2000

Postdoctoral Research Fellowship, UT Southwestern Medical Center at Dallas, 2000-2004

Assistant Instructor of Physiology, UT Southwestern Medical Center at Dallas, 2004-2005

Instructor of Physiology, UT Southwestern Medical Center at Dallas, 2006-2009

Principal Investigator, CAS Institute of Zoology, Beijing, 2009-present

Dr. Tie-Shan Tang is currently a principal investigator of Institute of Zoology, Chinese Academy of Sciences (CAS). Dr. Tang has spent much of his career studying the calcium signaling, mitochondrial regulation, and DNA repair pathway in health and diseases. Major findings of his work are that dysregulation of intracellular calcium signaling contributes to the pathogenesis of Huntington’s disease (HD), CFT and SCAs, and that defects in DNA repair are potential causative factors in some neurological diseases such as ALS and SCA3. Based on these key findings, corresponding therapeutic approaches were pursued both in vitro and in vivo. One of the therapeutics he has been developing involves a gene therapy method to stabilize neuronal calcium signaling and protect HD neurons from cell death. The Tang Lab is now exploring the frontiers of calcium signaling, mitochondrial regulation, DNA damage response and repair pathways in neurodevelopment and neurodegenerative diseases by combining biochemistry, molecular/cellular biology, genetics, drug screening, and mouse models. This will allow him to gain further insight into the molecular mechanism of neurological diseases (e.g. HD, PD, CFT, ALS, SCAs), and to develop novel/better therapeutic strategies. Ongoing research activities include: i) discovering novel players that govern intracellular calcium homeostasis and crosstalk among organelles; ii) ER-mitochondrial calcium signaling axis in health and disease; iii) dysregulation of calcium signaling, DNA damage response and epigenomics in neural stem cell self-renewal and depletion; and iv) designing new/better treatment and prevention strategies for neurodegenerative diseases and tumors.

Selected Publications:

Zhang C, Zhou B*, Gu F, Liu H, Wu H, Yao F, Zheng H, Fu H, Chong W, Cai S, Huang M, Ma X, Guo Z, Li T, Deng W, Zheng M, Ji Q, Zhao Y, Ma Y, Wang QE, Tang TS* and Guo C* (2022) Micropeptide PACMP Inhibition Elicits Synthetic-lethal Effects by Decreasing CtIP and Poly(ADP-ribosyl)ation. Mol Cell doi: 10.1016/j.molcel.2022.01.020. (in press)
Zheng S, Zhao D, Hou G, Zhao S, Zhang W, Wang X, Li L, Liang L, Tang TS, and Hu Y* (2022) iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca²⁺ homeostasis and control tumor growth and drug resistance. Proc Natl Acad Sci USA. doi: 10.1073/pnas.2111380119. (in press)
Tu Y, Li X, Zhu X, Liu X, Guo C, Jia D*, Tang TS* (2020) Determining the Fate of Neurons in SCA3: ATX3, a Rising Decision Maker in Response to DNA Stresses and Beyond. Front Cell Dev Biol 2020 Dec 23;8:619911. doi: 10.3389/fcell.2020.619911. (invited review)
Wang JQ, Zhu S, Wang Y, Wang F, An C, Jiang D, Gao L, Tu Y, Zhu X, Wang Y, Liu H, Gong J, Sun Z, Wang X, Liu L, Yang K, Guo C*, Tang TS* (2019) Miro2 supplies a platform for Parkin translocation to damaged mitochondria. Science Bulletin, 64: 730–747.
Huang M, Zhou B, Gong J, Xing L, Ma X, Wang F, Wu W, Shen H, Sun C, Zhu X, Yang Y, Sun Y, Liu Y, Tang TS*, Guo C* (2018) RNA-splicing factor SART3 regulates translesion DNA synthesis. Nucleic Acids Res 46(9): 4560-4574. doi: 10.1093/nar/gky220
Sun Z, Zhang H, Wang X, Wang QC, Zhang C, Wang JQ, Wang YH, An CQ, Yang KY, Wang Y, Gao F, Guo C*, Tang TS* (2018) TMCO1 is essential for ovarian follicle development by regulating ER Ca²⁺ store of granulosa cells. Cell Death Differ 25(9): 1686-1701. doi: 10.1038/s41418-018-0067-x.
Liu H, Tang TS, Guo C* (2018) Epigenetic profiles in polyglutamine disorders. Epigenomics 10(1): 9-25. doi: 10.2217/epi-2017-0089. (invited review)
Ma X, Liu H, Li J, Wang Y, Ding YH, Shen H, Yang Y, Sun C, Huang M, Tu Y, Liu Y, Zhao Y, Dong MQ, Xu P, Tang TS*, Guo C*. (2017) Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis. Nat Commun 2017 Dec 5; 8(1): 1941. doi: 10.1038/s41467-017-02164-1.
Gong J, Huang M, Wang F, Ma X, Liu H, Tu Y, Xing L, Zhu X, Zheng H, Fang J, Li X, Wang Q, Wang J, Sun Z, Wang X, Wang Y, Guo C*, Tang TS* (2017) RBM45 competes with HDAC1 for binding to FUS in response to DNA damage. Nucleic Acids Res 45(22): 12862-12876. doi: 10.1093/nar/gkx1102.
Tu Y, Liu H, Zhu X, Shen H, Ma X, Wang F, Huang M, Gong J, Li X, Wang Y, Guo C*, Tang TS* (2017) Ataxin-3 promotes genome integrity by stabilizing Chk1. Nucleic Acids Res 45(8): 4532-4549. doi: 10.1093/nar/gkx095.
Liu H, Li X, Ning G, Zhu S, Ma X, Liu X, Liu C, Huang M, Schmitt I, Wüllner U, Niu Y, Guo C*, Wang Q*, Tang TS* (2016) The Machado–Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53. PLoS Biol 14(11): e2000733. doi:10.1371/journal.pbio.2000733.
Wang QC, Zheng Q, Tan H, Zhang B, Li X, Yang Y, Yu J, Liu Y, Chai H, Wang X, Sun Z, Wang JQ, Zhu S, Wang F, Yang M, Guo C, Wang H, Zheng Q, Li Y#, Chen Q#, Zhou A*, Tang TS* (2016) TMCO1 is an ER Ca²⁺ load-activated Ca²⁺ (CLAC) channel. Cell 165(6): 1454-1466. doi: 10.1016/j.cell.2016.04.051.
Yang Y, Liu Z, Wang F, Temviriyanukul P, Ma X, Tu Y, Lv L, Lin YF, Huang M, Zhang T, Pei H, Chen BP, Jansen JG, de Wind N, Fischhaber PL, Friedberg EC, Tang TS*, Guo C* (2015) FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress. Nucleic Acids Res. 43(17):8325-8339. doi: 10.1093/nar/gkv737.
Li X, Liu H, Fischhaber PL*, Tang TS* (2015) Towards therapeutic targets for SCA3: insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance. Progress in Neurobiology 132: 34-58. doi: 10.1016/j.pneurobio.2015.06.004.
Qin Y, Guo T, Li G, Tang TS, Zhao S, Jiao X, Gong J, Gao F, Guo C, Simpson JL, Chen ZJ* (2015) CSB-PGBD3 Mutations Cause Premature Ovarian Failure. PLoS Genet. 2015 Jul 28; 11(7):e1005419. doi: 10.1371/journal.pgen.1005419.
Xie W, Wang JQ, Wang QC, Wang Y, Yao S*, Tang TS* (2015) Adult neural progenitor cells from Huntington’s disease mouse brain exhibit increased proliferation and migration due to enhanced Ca²⁺ ROS signals. Cell Proliferation 48(5): 517-531.
Liu Y, Yang Y, Tang TS, Zhang H, Wang Z, Friedberg E, Yang W, Guo C*. (2014) Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct. Proc Natl Acad Sci USA. 111(5):1789-1794. doi: 10.1073/pnas.1324168111.
Wang F, Fischhaber PL, Guo C, Tang TS* (2014) Epigenetic modifications as novel therapeutic targets for Huntington's disease. Epigenomics 6(3): 287-297. (invited review)
Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, Li X, Liu Z, Zhang T, Huang M, Friedberg E, Tang TS, Guo C*. (2013) Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. Nucleic Acids Research 41(22): 10312-10322. doi: 10.1093/nar/gkt793.
Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C*, Han C*, Tang TS* (2013) Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease. Human Molecular Genetics 22(18): 3641-3653.
Zhang X, Lv L, Chen Q, Yuan F, Zhang T, Yang Y, Zhang H, Wang Y, Qian L, Chen B, Zhang Y, Friedberg EC, Tang TS*, Guo C* (2013) Mouse DNA Polymerase Kappa Has A Functional Role in the Repair of DNA Strand Breaks. DNA Repair (Amst) 12(5):377-388.
Wang JQ, Chen Q, Wang X, Wang QC, Wang Y, Cheng HP, Guo C, Sun Q, Chen Q, Tang TS* (2013) Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington’s Disease. J Biol Chem 288(5): 3070-3084.
Wang Z, Wang F, Tang TS*, Guo C* (2012) The role of PARP1 in the DNA damage response and its application in tumor therapy. Front Med. 6(2):156-164. (invited review)
Guo C, Tang TS, Friedberg EC. (2010) SnapShot: Nucleotide Excision Repair. Cell vol 140(5): 754-754.e1.
Wang H, Chen X, Li Y, Tang TS* and Bezprozvanny I* (2010) Tetrabenazine is neuroprotective in Huntington’s disease mice. Molecular Neurodegeneration, 5:18
Tang TS, Guo C, Wang H, Chen X, Bezprozvanny I* (2009) Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model. J Neuroscience 29(5):1257-1266.
Chen X, Tang TS, Tu H, Nelson O, Pook M, Hammer R, Nukina N, Bezprozvanny I* (2008) Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3. J Neuroscience vol 28:12713-12724
Schneider JW, Gao Z, Li S, Farooqi M, Tang TS, Bezprozvanny I, Frantz D, Hsieh J* (2008) Small molecule activation of neuronal cell fate. Nat Chem Biol Vol 4(7): 408-410
Guo C, Tang TS, Bienko M, Dikic I and Friedberg EC* (2008) Requirements for the interaction of mouse Polκ with ubiquitin, and its biological significance. J Biol Chem 283 (8): 4658-4664.
Tang TS, Chen X, Liu J, Bezprozvanny I* (2007) Dopaminergic signaling and apoptosis of medium spiny neurons in Huntington’s disease. J Neuroscience vol 27: 7899-7910.
Guo C, Sonoda E, Tang TS, Parker JL, Bielen AB, Takeda S, Ulrich HD, Friedberg EC. (2006) REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo. Mol Cell 23(2):265-271.
Guo C, Tang TS, Bienko M, Sonoda E, Parker JL, Bielen AB, Takeda S, Ulrich HD, Dikic I, Friedberg EC. (2006) Ubiquitin-Binding Motifs in Rev1 Protein are Required for Its Role in the Tolerance of DNA Damage. Mol Cell Biol 26(23):8892-8900.
Tang TS, Slow E, Lupu V, Stavrovskaya IG, Sugimori M, Llinas R, Kristal BS, Hayden MR, Bezprozvanny I* (2005) Disturbed Ca²⁺ signaling and apoptosis of medium spiny neurons in Huntington's disease. Proc Natl Acad Sci USA. 102(7): 2602-2607.
Chen Y, Beffert U, Ertunc M, Tang TS, Kavalali ET, Bezprozvanny I, Herz J* (2005) Reelin modulates NMDA receptor activity in cortical neurons. J Neuroscience, Vol 25, pp 8209-8216.
Tang TS, Bezprozvanny I* (2004) Dopamine receptor-mediated Ca²⁺ signaling in striatal medium spiny neurons. J Biol Chem. 279 (40): 42082-42094.
Tu H, Tang TS, Wang Z, Bezprozvanny I* (2004) Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotiao) and protein kinase A. J Biol Chem. 279 (18): 9375-9382.
Tang TS, Tu H, Chan EY, Maximov A, Wang Z, Wellington CL, Hayden MR, Bezprozvanny I* (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) trisphosphate receptor type 1. Neuron 39(2): 227-239.
Tang, TS, Tu H, Wang Z, and Bezprozvanny I* (2003) Modulation of the type 1 inositol (1,4,5)-trisphosphate receptor function by PKA and PP1-alpha. J Neuroscience 23(2): 403-415.
Tang TS, Dong JB, Huang XY and Sun FZ (2000) Ca²⁺ oscillations induced by a cytosolic sperm protein factor are mediated by a maternal machinery which functions only once in mammalian eggs. Development 127(5): 1141-1150.

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