- Zheng, K.W., Zhang, J.Y., He, Y.D., Gong, J.Y., Wen, C.J., Chen,J.N., Hao, Y.H., Zhao, Y. and Tan, Z. (2020) Detection of genomic G-quadruplexes in living cells using a small artificial protein. Nucleic Acids Res., 48, 11706-11720.
- Zheng, K.W., Liu, C., Meng, Q., Hao, Y.H., Zheng, J.P., Li, W. and Tan, Z. (2020) One-Step High-Throughput Telomerase Activity Measurement of Cell Populations, Single Cells, and Single-Enzyme Complexes. ACS Omega, 5, 24666-24673.
- Zhang, J.Y., Xia, Y., Hao, Y.H. and Tan, Z. (2020) DNA:RNA hybrid G-quadruplex formation upstream of transcription start site. Sci Rep, 10, 7429.
- Wen, C.J., Gong, J.Y., Zheng, K.W., He, Y.D., Zhang, J.Y., Hao, Y.H. and Tan, Z. (2020) Targeting nucleic acids with a G-triplex-to-G-quadruplex transformation and stabilization using a peptide-PNA G-tract conjugate. Chem. Commun. (Camb.), 56, 6567-6570.
- He, Y.D., Zheng, K.W., Wen, C.J., Li, X.M., Gong, J.Y., Hao, Y.H., Zhao, Y. and Tan, Z. (2020) Selective Targeting of Guanine-Vacancy-Bearing G-Quadruplexes by G-Quartet Complementation and Stabilization with a Guanine-Peptide Conjugate. J. Am. Chem. Soc., 142, 11394-11403.
- Zheng, K.W., Zhang, J.Y. and Tan, Z. (2019) Characterization of Co-transcriptional Formation of G-Quadruplexes in Double-Stranded DNA. Methods Mol. Biol., 2035, 243-255.
- Xia, Y., Zheng, K.W., He, Y.D., Liu, H.H., Wen, C.J., Hao, Y.H. and Tan, Z. (2018) Transmission of dynamic supercoiling in linear and multi-way branched DNAs and its regulation revealed by a fluorescent G-quadruplex torsion sensor. Nucleic Acids Res., 46, 7418-7424.
- Zheng, K.W., He, Y.D., Liu, H.H., Li, X.M., Hao, Y.H. and Tan, Z. (2017) Superhelicity Constrains a Localized and R-Loop-Dependent Formation of G-Quadruplexes at the Upstream Region of Transcription. ACS Chem. Biol., 12, 2609-2618.
- Zhao, Y., Zhang, J.Y., Zhang, Z.Y., Tong, T.J., Hao, Y.H. and Tan, Z. (2017) Real-Time Detection Reveals Responsive Cotranscriptional Formation of Persistent Intramolecular DNA and Intermolecular DNA:RNA Hybrid G-Quadruplexes Stabilized by R-Loop. Anal. Chem., 89, 6036-6042.
- Li, X.M., Zheng, K.W., Hao, Y.H. and Tan, Z. (2016) Exceptionally Selective and Tunable Sensing of Guanine Derivatives and Analogues by Structural Complementation in a G-Quadruplex. Angew. Chem. Int. Ed. Engl., 55, 13759-13764.
- Liu, H.h., Zheng, K.w., He, Y.d., Chen, Q., Hao, Y.h. and Tan, Z. (2016) RNA G-quadruplex formation in defined sequence in living cells detected by bimolecular fluorescence complementation. Chem. Sci., 7, 4573-4581.
- Li, X.M., Zheng, K.W., Zhang, J.Y., Liu, H.H., He, Y.D., Yuan, B.F., Hao, Y.H. and Tan, Z. (2015) Guanine-vacancy-bearing G-quadruplexes responsive to guanine derivatives. Proc. Natl. Acad. Sci. USA, 112, 14581-14586.
- Liu, J.Q., Xiao, S., Hao, Y.H. and Tan, Z. (2015) Strand-Biased Formation of G-Quadruplexes in DNA Duplexes Transcribed with T7 RNA Polymerase. Angew. Chem. Int. Ed. Engl., 54, 8992-8996.
- Wu, R.Y., Zheng, K.W., Zhang, J.Y., Hao, Y.H. and Tan, Z. (2015) Formation of DNA:RNA Hybrid G-Quadruplex in Bacterial Cells and Its Dominance over the Intramolecular DNA G-Quadruplex in Mediating Transcription Termination. Angew. Chem. Int. Ed. Engl., 54, 2447-2451.
- Tan, Z., Tang, J., Kan, Z.Y. and Hao, Y.H. (2015) Telomere G-Quadruplex as a Potential Target to Accelerate Telomere Shortening by Expanding the Incomplete End-Replication of Telomere DNA. Curr. Top. Med. Chem., 15, 1940-1946.
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Xiao, S., Zhang, J.Y., Wu, J., Wu, R.Y., Xia, Y., Zheng, K.W., Hao, Y.H., Zhou, X. and Tan, Z. (2014) Formation of DNA:RNA Hybrid G-Quadruplexes of Two G-Quartet Layers in Transcription: Expansion of the Prevalence and Diversity of G-Quadruplexes in Genomes. Angew. Chem. Int. Ed. Engl., 53, 13110-13114.
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Zheng, K.W., Wu, R.Y., He, Y.D., Xiao, S., Zhang, J.Y., Liu, J.Q., Hao, Y.H. and Tan, Z. (2014) A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site. Nucleic Acids Res., 42, 10832-10844.
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Zhang, J.Y., Zheng, K.W., Xiao, S., Hao, Y.H. and Tan, Z. (2014) Mechanism and Manipulation of DNA:RNA Hybrid G-Quadruplex Formation in Transcription of G-Rich DNA. J. Am. Chem. Soc., 136, 1381-1390.
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Zheng, K.W., Xiao, S., Liu, J.Q., Zhang, J.Y., Hao, Y.H. and Tan, Z. (2013) Co-transcriptional formation of DNA:RNA hybrid G-quadruplex and potential function as constitutional cis element for transcription control. Nucleic Acids Res., 41, 5533-5541.
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Zhang, C., Liu, H.H., Zheng, K.W., Hao, Y.H. and Tan, Z. (2013) DNA G-quadruplex formation in response to remote downstream transcription activity: long-range sensing and signal transducing in DNA double helix. Nucleic Acids Res., 41, 7144-7152.
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Xiao, S., Zhang, J.Y., Zheng, K.W., Hao, Y.H. and Tan, Z. (2013) Bioinformatic analysis reveals an evolutional selection for DNA:RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded animals. Nucleic Acids Res., 41, 10379-10390.
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Wang, F., Tang, M.L., Zeng, Z.X., Wu, R.Y., Xue, Y., Hao, Y.H., Pang, D.W., Zhao, Y. and Tan, Z. (2012) Telomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cells. Proc. Natl. Acad. Sci. USA, 109, 20413-20418.
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Xue, Y., Liu, J.Q., Zheng, K.W., Kan, Z.Y., Hao, Y.H. and Tan, Z. (2011) Kinetic and Thermodynamic Control of G-Quadruplex Folding. Angew. Chem. Int. Ed., 50, 8046-8050.
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Wang, Q., Liu, J.Q., Chen, Z., Zheng, K.W., Chen, C.Y., Hao, Y.H. and Tan, Z. (2011) G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase. Nucleic Acids Res., 39, 6229-6237.
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Chen, C.Y., Wang, Q., Liu, J.Q., Hao, Y.H. and Tan, Z. (2011) Contribution of Telomere G-Quadruplex Stabilization to the Inhibition of Telomerase-Mediated Telomere Extension by Chemical Ligands. J. Am. Chem. Soc., 133, 15036-15044.
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Zheng, K.W., Zhang, D., Zhang, L.X., Hao, Y.H., Zhou, X. and Tan, Z. (2011) Dissecting the strand folding orientation and formation of g-quadruplexes in single- and double-stranded nucleic acids by ligand-induced photocleavage footprinting. J. Am. Chem. Soc., 133, 1475-1483.
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Wang, Q., Ma, L., Hao, Y.H. and Tan, Z. (2010) Folding equilibrium constants of telomere g-quadruplexes in free state or associated with proteins determined by isothermal differential hybridization. Anal. Chem., 82, 9469-9475.
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Liu, J.Q., C.Y. Chen, Y. Xue, Y.H. Hao, & Z. Tan, (2010) G-Quadruplex Hinders Translocation of BLM Helicase on DNA: A Real-Time Fluorescence Spectroscopic Unwinding Study and Comparison with Duplex Substrates. J Am Chem Soc, 132(30): 10521-7.
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Zheng, K.W., Z. Chen, Y.H. Hao, & Z. Tan, (2010) Molecular crowding creates an essential environment for the formation of stable G-quadruplexes in long double-stranded DNA. Nucleic Acids Res, 38(1): 327-38.
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Chen, Z., K.W. Zheng, Y.H. Hao, & Z. Tan, (2009) Reduced or Diminished Stabilization of the Telomere G-Quadruplex and Inhibition of Telomerase by Small Chemical Ligands under Molecular Crowding Condition. J Am Chem Soc, 131: 10430-10438.
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Yuan, B.F., X.Y. Zhuang, Y.H. Hao, & Z. Tan, (2008) Kinetics of base stacking-aided DNA hybridization. Chem Commun (Camb), (48): 6600-6602.
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Wang, F., Y. Zhao, Y. Hao, & Z. Tan, (2008) Identification of low-abundance alternatively spliced mRNA variants by exon exclusive reverse transcriptase polymerase chain reaction. Anal Biochem, 383: 307-310.
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Tang, J., Z.Y. Kan, Y. Yao, Q. Wang, Y.H. Hao, & Z. Tan, (2008) G-quadruplex preferentially forms at the very 3' end of vertebrate telomeric DNA. Nucleic Acids Res, 36(4): 1200-8.
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Zhuang, X.Y., J. Tang, Y.H. Hao, & Z. Tan, (2007) Fast detection of quadruplex structure in DNA by the intrinsic fluorescence of a single-stranded DNA binding protein. J Mol Recognit, 20(5): 386-91.
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Yuan, B.F., Y. Xue, M. Luo, Y.H. Hao, & Z. Tan, (2007) Two DNAzymes targeting the telomerase mRNA with large difference in Mg2+ concentration for maximal catalytic activity. Int J Biochem Cell Biol, 39(6): 1119-29.
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Yao, Y., Q. Wang, Y.H. Hao, & Z. Tan, (2007) An exonuclease I hydrolysis assay for evaluating G-quadruplex stabilization by small molecules. Nucleic Acids Res, 35(9): e68.
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Xue, Y., Z.Y. Kan, Q. Wang, Y. Yao, J. Liu, Y.H. Hao, & Z. Tan, (2007) Human telomeric DNA forms parallel-stranded intramolecular G-quadruplex in K+ solution under molecular crowding condition. J Am Chem Soc, 129(36): 11185-91.
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Kan, Z.Y., Y. Lin, F. Wang, X.Y. Zhuang, Y. Zhao, D.W. Pang, Y.H. Hao, & Z. Tan, (2007) G-quadruplex formation in human telomeric (TTAGGG)4 sequence with complementary strand in close vicinity under molecularly crowded condition. Nucleic Acids Res, 35(11): 3646-53.
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Kan, Z.Y., Y. Yao, P. Wang, X.H. Li, Y.H. Hao, & Z. Tan, (2006) Molecular crowding induces telomere G-quadruplex formation under salt-deficient conditions and enhances its competition with duplex formation. Angew Chem Int Ed Engl, 45(10): 1629-32.
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Zhao, Y., Z.X. Zeng, Z.Y. Kan, Y.H. Hao, & Z. Tan, (2005) The folding and unfolding kinetics of the i-motif structure formed by the C-rich strand of human telomere DNA. Chembiochem, 6(11): 1957-60.
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Zeng, Z.X., Y. Zhao, Y.H. Hao, & Z. Tan, (2005) Tetraplex formation of surface-immobilized human telomere sequence probed by surface plasmon resonance using single-stranded DNA binding protein. J Mol Recognit, 18(3): 267-71.
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Shao, L., Q.H. Li, J. Wang, & Z. Tan, (2005) Fragmentation and rapid shortening of telomere in HeLa cells in the early phase of hydroxyl radical-induced apoptosis. Cancer Biol Ther, 4(3): 336-41.
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Li, W.G., Q.H. Li, & Z. Tan, (2005) Epigallocatechin gallate induces telomere fragmentation in HeLa and 293 but not in MRC-5 cells. Life Sci, 76(15): 1735-46.
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Li, W.G., Q.H. Li, & Z. Tan, (2005) Detection of telomere damage as a result of strand breaks in telomeric and subtelomeric DNA. Electrophoresis, 26(3): 533-6.
