State Key Laboratory of Biomembrane and Membrane Biotechnology

Name:	WANG, Qiang
Subject:	Cell Biology
Tel/Fax:	+86-10-64807895 /
E-mail:	qiangwang@ioz.ac.cn
Address:	State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Siences, A3 Datun Road, Chaoyang District, Beijing 100101, P.R.China
More:	Group of Developmental Signaling 中文

Resume:

Dr. Wang is a professor at State Key Laboratory of Membrane Biology in the Institute of Zoology, Chinese Academy of Sciences. He received his doctoral degree from Shandong University, and then preformed a post-doctoral study at Tsinghua University. Dr. Wang is a recipient of National Science Fund for Excellent Young Scholars. He mainly works on how a relatively uniform embryo becomes asymmetric during early developmental stages, and has made significant progress in elucidating the molecular mechanisms of embryonic body patterning that establishes the dorsal-ventral, anterior-posterior, and left-right axes. The related papers are published on the famous international academic journals such as Developmental Cell, Nature Communications, Science Advances, Blood, PLOS Biology, PLOS Genetics, and Journal of Neuroscience etc.

Research Interests:

Our lab investigates how a relatively uniform embryo becomes asymmetric during early developmental stages. This asymmetry consists of two aspects, the initial cell fate decision and the embryonic body patterning that establishes the dorsal-ventral, anterior-posterior, and left-right axes. The function of genes and signal pathways like TGF-β, BMP and Wnt are being studied in zebrafish embryos and mammalian cell lines using genetic, biochemical and molecular approaches. Research progresses on these great mysteries will help us to get a better understanding of how a fertilized egg gives rise to a live baby.

Selected Publications:

Yan Y, Ning G, Li L, Liu J, Yang S, Cao Y, Wang Q^*. (2019). The BMP ligand Pinhead together with Admp supports the robustness of embryonic patterning. Science Advances 5, eaau6455.
Liu J, Zhu C, Ning G, Yang L, Cao Y, Huang S^*, Wang Q^*. (2019). Chemokine signaling links cell-cycle progression and cilia formation for left-right symmetry breaking. PLOS Biology 17, e3000203.
Li L, Ning G, Yang S, Yan Y, Cao Y, Wang Q^*. (2019). BMP signaling is required for nkx2.3-positive pharyngeal pouch progenitor specification in zebrafish. PLOS Genetics 15, e1007996.
Wei S., Dai M., Liu Z., Ma Y., Shang H., Cao Y., Wang Q^*. (2017). The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Cell Research 27, 202-225.
Liu Z, Ning G, Xu R, Cao Y, Meng A^*, Wang Q^*. (2016). Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation. Nature Communications 7, 12603.
Liu H., Li X., Ning G., Zhu S., Ma X., Liu X., Liu C., Huang M., Schmitt I., Wüllner U., Niu Y., Guo C.^*, Wang Q.^*, Tang TS^*. (2016). The Machado-Joseph disease deubiquitinase Ataxin-3 regulates the stability and apoptotic function of p53. PLOS Biology 14, e2000733.
Ma Y, Liu X, Liu Z, Wei S, Shang H, Xue Y, Cao Y, Meng A^*, Wang Q^*. (2015). The chromatin remodeling protein Bptf promotes posterior neuroectodermal fate by enhancing Smad2-activated wnt8a expression. Journal of Neuroscience 35, 8493- 8506.
Ning, G., Liu, X., Dai, M., Meng, A.^*, and Wang, Q^*. (2013). MicroRNA-92a upholds Bmp signaling by targeting noggin3 during pharyngeal cartilage formation. Developmental Cell 24, 283-295.
Wang, Q., Huang, Z., Xue, H., Jin, C., Ju, X.L., Han, J.D., and Chen, Y.G^*. (2008). MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood 111, 588-595.
Ma, J^#, Wang, Q^#, Fei, T., Han, J.D., and Chen, Y.G^*. (2007). MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood 109, 987-994. (^#Co-first author)

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