- 2018-02-28mTOR masters monocyte/macrophage development
Monocyte/macrophage plays a critical role in innate immunity against invading pathogens and tissue repair during the period of inflammation resolution. However, the molecular mechanism underlying the development of monocyte/mac...... - 2017-11-20Endothelial-specific m6A modulates mouse hematopoietic stem and progenitor cell development via Notch signaling
Hematopoietic stem cells (HSCs) can give rise to all blood lineages, including erythrocyte, myelocyte and lymphocyte, and maintain lifelong hematopoiesis in vertebrates. However, the limited source of matched donor-derived HSCs...... - 2017-01-17Lv et al found that 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival.
Hematopoietic stem and progenitor cells (HSPCs) possess the capacity to produce more than 10 different functional specialized cell lineages, as well as the ability to self-renew. HSPC transplantation is the foundation to treat ...... - 2016-10-24Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation
The TGF-β superfamily consists of more than forty secretory proteins, which are divided into TGF-β/Activin/Nodal and BMP/GDF/MIS subfamilies according to their functional differences. Nodal is a member of the TGF-β superfami...... - 2016-09-06Studies uncover a long non-coding RNA that is critical to air pollution-induced lung cancer
Lung cancer is the most common cause of death from cancer and is estimated to have been responsible for nearly one in five deaths (1.59 million deaths, 19.4% of the total) in 2012 worldwide. People have known that lung cancer i...... - 2016-09-01Syndecan-4 suppresses Antiviral Signaling by Deubiquitinating RIG-I via CYLD
The innate immune system acts as the first line of the host defenses, rapidly detecting and eliminating invading pathogens such as viruses, bacteria and fungi. Meanwhile, overproduction of pro-inflammatory cytokines potentially...... - 2016-08-25Scientists identified a new role of RNA polymerase III complex in regulating hematopoietic stem and progenitor cell maintenance
DNA-directed RNA polymerase III complex (Pol III) is a specialized enzyme responsible for transcription of small noncoding RNAs (snRNAs) including 5S rRNA, tRNAs and 7SL RNA etc. It is the most complex RNA polymerase that compr...... - 2016-08-18Ca2+ load-activated Ca2+ (CLAC) release channel has been identified
Calcium ion (Ca2+) is a highly versatile intracellular signal that controls many different cellular functions such as contraction, secretion, memory formation, gene transcription, cell growth and cell death. Endoplasmic reticul...... - 2015-12-22Unexpected role of inflammatory signaling in hematopoietic stem cell development: its role beyond inflammation
Under pathological conditions like infection and inflammation, hematopoietic stem and progenitor cells (HSPCs) can produce all types of immune effector cells through inflammatory signaling stimulation for the body homeostasis. ... - 2014-07-18Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling
Hematopoietic stem cells (HSCs) are a group of hematopoietic progenitor cells that can differentiate into all kinds of mature blood cells (including erythroid, myeloid and lymphoid cells) that circulate through the body to main......
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