- 2014-07-04TLR ligands and IFN-γ exhibit antagonistic effects on protease HTRA1 expression in rheumatoid arthritis
Rheumatoid arthritis (RA) is a common autoimmune disease with a prevalence of about 1% worldwide. RA is characterized by chronic inflammation and high levels of destructive mediators in the synovium, which leads to cartilage an...... - 2014-03-13Inhibition of endothelial ERK signaling by Smad1/5 is essential for hematopoietic stem cell emergence
Hematopoietic stem cells (HSCs) are a group of multipotent hematopoietic progenitor cells that can differentiate into all blood lineages to maintain normal life activities. Hematopoietic stem cell transplantation (HSCT) has bec...... - 2013-12-19CIP2A inhibitor shows promise in preclinical study for lung cancer
Lung cancer is the leading cause of cancer deaths worldwide, killing 1.4 million people annually. Therefore, there is an urgent need to develop new targeted therapies for this deadly disease....
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